How It Works:
MOTS-c is a mitochondrial-encoded peptide with 16-aa’s encoded within the 12S rRNA locus of mtDNA in human cells. MOTS-C can
translocate into the nucleus in response to metabolic stress and regulation of adaptive nuclear gene expression. This allows the peptide to
promote resistance of metabolic stress by upregulating the mitochondrial genome. Upregulating these genes encourages mitochondrial
biogenesis. MOTS-c inhibits the methionine-folate cycle resulting in purine synthesis, increase in PCG-1(a key regulator of energy metabolism),
and AICAR (5- Aminoimidazole-4-carboxamide ribonucleotide) accumulation which activates AMPK (5’- adenosine monophosphate-activated
protein kinase). This acts as an energy sensor by monitoring the ratio of AMP and ATP. AMPK restores homeostasis by initiating catabolic
processes for ATP production in case of energy deficits. In addition, literature suggest that MOTS-c decreases insulin resistance and increases
GLUT4 uptake in muscle.
Key Benefits:
The peptide is mainly used for weight loss (regulating muscle and fat metabolism) and energy (cell survival in toxic conditions). MOTS-c
is consistently used by sports performance athletes to enhance one’s performance. It also displays a promising effect in longevity.
Content & Potency:
Injectable
20mg Vial: Reconstitute 2ml with BWFI (10mg/ml – 2ml) Inject 10ml subcutaneously once a week
